SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.* NOW® SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation. Natural color variation may occur in this product. Take 1 tablet 2 to 4 times daily, preferably on an empty stomach. Refrigeration recommended after opening.

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Health Concern: Joint Health & Support Mood Support



These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.



Ingredients: Amount per Serving % Daily Value * Daily Value not established. SAMe (S-Adenosyl-L-Methionine) (from S-Adenosyl-L-Methionine Disulfate Tosylate) 400 mg * Other Ingredients: Cellulose, Croscarmellose Sodium, Magnesium Stearate (vegetable source), Silica, Stearic Acid (vegetable source), Ascorbic Acid, Citric Acid and Enteric Coating (water, methacrylic acid, methyl methacrylate, glycerin). Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.


Dosage: 1 Tablet

Instructions: Take 1 tablet 2 to 4 times daily, preferably on an empty stomach. Refrigeration recommended after opening.


Nervous System Support
Assembled Product Weight
0.25 oz
Assembled Product Dimensions (L x W x H)
2.13 x 2.13 x 4.00 Inches

Customer Comments

What others said when purchasing this item
Dr prescribed
Mir, purchased on August 31, 2021
lmprove joint health
Janet, purchased on March 12, 2021
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Average Rating:(5.0)out of 5 stars

Works better than antidepressants

October 22, 2019

Love it, this is my 4 or 5 bottle, lost count, makes me feel wonderful, I only take 400mg a day , first thing in the morning

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Reviewed by ChefkimChefkim
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Average Rating:(5.0)out of 5 stars

Vitamins and supplements- SamE

October 5, 2017 has the same products we normally buy from other supplements sites at about the same price- the winning difference is shipping speed- ships faster- very fast. Other sites can take 10-12 days, took 3- this beats Amazon.

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Average Rating:(1.0)out of 5 stars

They don't check Expiration dates..

October 11, 2020
Verified purchase

They sold me an expired product...It expired back in April this year...

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Reviewed by Madcat53Madcat53
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Are these pills individually wrapped?
by BobbieJune 18, 2017
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1. No, the pills are not individually wrapped.
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Last answer: June 23, 2017

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